Atypical mitochondrial inheritance patterns in eukaryotes
نویسندگان
چکیده
منابع مشابه
Mendelian and Atypical Patterns of Inheritance
INTRODUCTION Mendelian inheritance is based on the transmission of a single gene on a dominant, recessive or X-linked pattern. Discoveries on DNA structure, the genetic code, the genome and the observation that some characters and hereditary diseases do not follow classical mendelian inheritance have led researchers to define other patterns of transmission, referring particularly to multifactor...
متن کاملMitochondrial DNA Mutations, Pathogenicity and Inheritance
Mitochondria contain their own DNA (mtDNA), which codes for 13 proteins (all subunits of the respiratory chain complexes), 22 tRNAs and 2 rRNAs. Several mtDNA point mutations as well as deletions have been shown to be causative in well-defined mitochondrial disorders. A mixture of mutated and wild type mtDNA (heteroplasmy) is found in most of these disorders. Inheritance of mtDNA is maternal, a...
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Disease-associated misfolded proteins or proteins damaged due to cellular stress are generally disposed via the cellular protein quality-control system. However, under saturating conditions, misfolded proteins will aggregate. In higher eukaryotes, these aggregates can be transported to accumulate in aggresomes at the microtubule organizing center. The fate of cells that contain aggresomes is cu...
متن کاملPatterns of inheritance
In diploid organisms each body cell (or 'somatic cell') contains two copies of the genome. So each somatic cell contains two copies of each chromosome, and two copies of each gene. The exceptions to this rule are the sex chromosomes that determine sex in a given species. For example, in the XY system that is found in most mammals including human beings males have one X chromosome and one Y chro...
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ژورنال
عنوان ژورنال: Genome
سال: 2015
ISSN: 0831-2796,1480-3321
DOI: 10.1139/gen-2015-0090